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Soluble Human Intercellular Adhesion Molecule-1 (sICAM-1) ELISA

Intercellular Adhesion Molecule-1 (ICAM-1) is a member of the immunoglobulin superfamily and functions as a ligand for the Lymphocyte Function-Associated Antigen-1, which mediates lymphocyte adhesion.  ICAM-1 can be expressed on non-hematopoietic cells of many lineages such as vascular endothelial cells, thymic epithelial cells, other epithelial cells and fibroblasts and on hematopoietic cells such as macrophages, B and T-lymphocytes, and dendritic cells. ICAM-1 is inducible on fibroblasts and endothelial cells by inflammatory mediators such as IL-1, TNF and IFN-g within a few hours and is correlated to the infiltration of lymphocytes into inflammatory lesions. ICAM-1 seems to be the initial marker of inflammatory reactions. The role of ICAM-1 as a disease marker has been demonstrated for a number of different indications and pathological situations.

The sICAM-1 assay is an enzyme-linked immunosorbent assay for the quantitative detection of soluble ICAM-1 in cell culture supernatants, human serum, plasma, urine, amniotic fluid, bile, or other body fluids. The standard curve spans the range of 0.2-10.0 ng/ml and the minimum detectable level is 0.06 ng/ml. Specimens are diluted appropriately to fall within this range. The range of ICAM-1 concentration in normal healthy human serum is 130-300 ng/ml with a mean level of 230.3 ± 47.4 ng/ml. Significantly higher sICAM-1 levels are found in some cancers, HIV, hepatitis B, graft rejection, transplant rejection, arthritis, psoriasis, and diabetes. A decrease in sICAM-1 level can be used to monitor myocardial infarction, ischemia, and reperfusion. This ELISA is for research use only, and is not to be used in diagnostic or therapeutic procedures.

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