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Cytokines and Growth Factors

Cytokines are small cell-signaling protein molecules for intercellular communication, secreted by numerous cells. The term "cytokine" has been used to refer to the immunomodulating agents, such as interleukins and interferons, and are also involved in adhesion interactions.  The distinction between cytokines and hormones is often not clear, and  anatomic and structural distinctions between the two are fading. Protein hormones such as insulin, are secreted from discrete glands, and  circulate in nanomolar concentrations that usually vary by less than one order of magnitude. Virtually all nucleated cells, but especially endo/epithelial cells and resident macrophages are potent producers of cytokines such as  IL-1, IL-6, and TNF-alfa which circulate in picomolar concentrations and increase several orders of magnitude during trauma or infection. Measurement of cytokines in plasma offers a window in the regulation of inflammation and adhesion. If your studies require the measurment of different cytokines, growth factors or adhesion molecules than are listed, please give us a call, we are likely able to provide such a test.

A excellent detailed description on the world of cytokines can be found online at: Horst Ibelgaufts' COPE: Cytokines and cells Online Pathfiner Encyclopedia

 

Growth Factors include VEGF, TGFb, EPO, and sTfR.