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Nitric Oxide (NOx)

 

In biological systems, nitric oxide (NO) is produced from the enzymatic oxidation of arginine. NO is an important messenger molecule involved in many physiological and pathological processes including vasodilation, inhibition of platelet aggregation, neurotransmission, and activation of smooth muscle proliferation. Appropriate levels of NO production are important in protecting an organ such as the liver from ischemic damage. In solution, NO reacts with molecular oxygen to form nitrite, and with oxyhemoglobin and superoxide anion to form nitrate.

The Sievers Nitric Oxide Analyzer (NOA) is used for measurement of NO in exhaled breath and measurement of nitrite and nitrate in biological fluids and other liquid samples. This instrument is a high-sensitivity detector for measuring NO based on a chemiluminescent reaction between NO and ozone (samples are first treated to reduce nitrite and nitrate to NO). The detection limit for measurement of NO and its reaction products in liquid samples is ~ 1 picomole. The detection range is nanomolar to millimolar. This instrument is for research use only and is not for use in diagnostic procedures.

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