Red Blood Cell Lab
Meet our Staff

Laboratory Services
Routine Hemoglobinopathy
Molecular Assays

Linear Array
Multiplex Gap PCR
DNA sequencing
Multiplex Ligation probe amplification

Special Hemoglobin Tests
Red Cell Function Tests
Blood Analysis
Data Evaluation

Study Facilitation
Database Development
Assay Development

Sickle Cell Disease
Other Hemoglobinopathies

Red Cells
Red Cell Membranes
Red Cell Lipids
Red Cell Metabolism

Financial Policies
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Clinical Diagnostics and Research tools

Molecular Assays

Molecular techniques expand  the analysis of hemoglobinopathies. The Linear Array assay is a multiplexed reverse dot blot genotyping method, used to simultaneously test for a panel of  common beta globin variants (Hb S, C, E, D, and O), as well as majority (>95%) of common beta-thalassemia mutations. The Multiplex Gap PCR assay (amplification using oligo-primers flanking deletion breakpoints) is used to detect common alpha thalassemia deletion mutations, alpha globin gene duplications, and other globin gene deletions, such as Hb Lepore and HPFH. DNA sequence analysis of alpha, beta or gamma globin genes is performed to definitively identify unknown point mutations or sequence variation.  
Multiplex Ligation-dependent Probe Amplification (MLPA) is used to identify large or unknown alpha-thalasssemia or beta-thalassemia deletions.

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Clinical Diagnostics and Research tools