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Red Blood Cell Lab
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Laboratory Services
Routine Hemoglobinopathy
Molecular Assays
Special Hemoglobin Tests
Red Cell Function Tests
Blood Analysis
Data Evaluation

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Hemoglobinopathies
Sickle Cell Disease
Thalassemia
Other Hemoglobinopathies

Red Cells
Red Cell Membranes
Red Cell Lipids
Red Cell Metabolism

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Laboratory Services

dripThe Red Blood Cell Laboratory at CHORI combines the efforts of the Hemoglobinopathy Reference Laboratory and the Red Cell Research Laboratory to serve as a resource to aid in the diagnosis of clinically relevant hemoglobinopathy and red cell disorders as well as to provide support for translational research studies focussed on sickle cell disease and thalassemia, and other red cell disorders.

We offer both clinical diagnostics and research laboratory assays.

Clinical Diagnostics are performed under CLIA and CAP licensure and include assays for Routine Hemoglobinopathy Testing, Molecular Testing, for sickling disorders, alpha and beta thalassemias, Special Tests for other hemoglobin disorders, and Red Cell Function Tests. In addition to their use for clinical diagnostics, these tests can also be applied to research studies.

The laboratory prides itself on delivering high quality diagnostic testing services in a timely fashion and has established strong working relationships with medical and research professionals at institutions across the country.

Research Laboratory Assays are performed under best laboratory practices and include Red Cell Function Tests, and Blood Analysis. These assays are essential components of translational research studies, but are not licensed for clinical diagnosis.

In addition to these assays, the laboratory provides support in data analysis and is a resource for the planning and execution of translational studies in sickle cell disease and thalassemia.

With a focus on quality control, rapid turn-around time, and active working relationships with state NBS programs, cord blood programs, clinical and research groups in the United States and internationally, the Red Blood Cell Laboratory has established itself as a leader in hemoglobinopathy diagnostics and research.

Routine analysis currently performed by the laboratory are indicated below. We will also perform various assays on an "as needed" basis for specific clinical and translational studies. On request we can develop new assays required for your study. Please contact us.

Clinical Diagnostics

Research lab assays

Routine Hemoglobinopathy Red Cell Function
Cellulose acetate electrophoresis (CAE) Advia 120 analysis
Citrate agar acid electrophoresis Reticulocytes
Isoelectric focusing (IEF) Erythropoietin (EPO)
Cation exchange HPLC Blood flow
Free Erythrocyte Protoporphyrin (FEP) Ektacytometry
Counts of  pitted red blood cells (Pit count) Oxygen Affinity
Sickle Solubility Test (SST) PS exposure
Red cell survival
Molecular assays
Linear Array Blood analysis
Multiplex Gap PCR Advia 120 analysis
DNA sequencing Amino Acid composition
Multiplex Ligation Probe Amplification (MPLA)
NO metabolism
Special Hb Tests Arginase protein and activity
Heat Stability Cell free hemoglobin
Isopropanol stability Lactate dehydrogenase (LDH)
Exhaled NO (NOex)
Red Cell Function Nitrite and Nitrate (NOx)
Ektacytometry (EKTA)
Hemostasis
D-dimer
Fragment 1+2
Thrombin-Antithrombin (TAT)
Tissue Factor (TF)
 
Cytokines & Growth factors
Cytokine panel 1
Cytokine panel 2
TGF beta
VEGF
 
Adhesion Molecules
Adhesion factors
L-Selectin (Lsel)
E-Selectin (Esel)
P-Seectin (Psel)
ICAM1
ICAM3
VCAM
 
Inflammation
sPLA2 concentration and  activity
IAP
CRP
sCD40L